Caged

Caged compounds are light-sensitive probes that functionally encapsulate biomolecules in an inactive form. Irradiation liberates the trapped molecule, permitting targeted perturbation of a biological process. Uncaging technology and fluorescence microscopy are 'optically orthogonal': the former allows control, and the latter, observation of cellular function. Used in conjunction with other technologies (for example, patch clamp and/or genetics), the light beam becomes a uniquely powerful tool to stimulate a selected biological target in space or time. Here I describe important examples of widely used caged compounds, their design features and synthesis, as well as practical details of how to use them with living cells.

Caged

BibGuru offers more than 8,000 citation styles including popular styles such as AMA, ASA, APSA, CSE, IEEE, Harvard, Turabian, and Vancouver, as well as journal and university specific styles. Give it a try now: Cite I know why the caged bird sings now! 041b061a72